Anti-Wrinkle Day Cream with SPF Protection and Collagen

Anti-Wrinkle Day Cream with SPF Protection and Collagen

€45,00
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122 Orders in last 24 Hours

The Cream SPF 25

Anti-Wrinkle Day Cream with SPF Protection and Collagen

Reviews

9 types of collagen + UVA protection

Developed by a team of experts

Clinically proven results

Smoother skin in just 28 days

Stimulates collagen synthesis in the skin

Protects against UVA radiation-induced collagen degradation

122 Orders in last 24 Hours

The Cream SPF 25

Anti-Wrinkle Day Cream with SPF Protection and Collagen

Anti-Wrinkle Day Cream with SPF Protection and Collagen

4.9 · Reviews

9 types of collagen + UVA protection

Developed by a team of experts

Clinically proven results

Smoother skin in just 28 days

Stimulates collagen synthesis in the skin

Protects against UVA radiation-induced collagen degradation

One-time payment

-20%

€36,00

€45,00

Attention: For certain special offers (e.g., discounts or exclusive promotions), promotional codes cannot be applied additionally. If you have a promotional code, you will be able to see directly in the checkout process whether it is valid for the selected offer or not.

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About the Seller

The cream was designed to protect and stimulate the level of collagen in the skin, preventing degradation and promoting its production.

Since collagen is an essential component of the skin matrix, the action of the cream brings significant improvements to the health and function of the skin.

With regular use, it provides a smoother, firmer, and more radiant complexion, visibly improving the skin.

Formulated with an advanced complex of collagen, peptides, stabilized vitamin C, and plant stem cells, the cream works synergistically to combat visible signs of aging and restore the skin's natural vitality.

Thanks to advanced UV filters (SPF 25, PA+++), it offers daily protection against UVA/UVB rays and blue light — factors responsible for collagen degradation and loss of firmness.

21Collagen SPF25 Cream is a complete daily treatment, combining stimulation, protection, and deep hydration of the skin — providing a visible anti-aging effect and a brighter, more even, and healthier complexion.

Clinically proven efficacy*

+30.8% increase in type I collagen synthesis (in vitro)
-43.3% reduction in collagen degradation caused by UVA (in vitro)+14.5% increase in skin elasticity (in 28 days)
-11.2% reduction in wrinkle volume (in 28 days)

*Studies conducted by Bionos Biotech (Valencia, Spain), according to ISO 9001:2015 and GCP standards.

1. Stimulates natural collagen production

The innovative formula with 9 types of collagen, stabilized vitamin C, and a multi-peptide complex works synergistically to support natural collagen synthesis and improve skin structure.

Result: firmer, softer skin with visibly increased elasticity.

2. Reduces collagen degradation caused by UVA rays and external factors

Advanced UV filters (SPF 25, PA+++) effectively protect dermal collagen fibers from photo-induced degradation and premature aging.

Result: prevention of loss of skin tone and firmness.

3. Intense hydration and restoration of the skin barrier

Collagen, aloe vera juice, and botanical extracts maintain hydration in the skin layers, reduce transepidermal water loss, and strengthen the epidermis's natural barrier.

Result: smooth, velvety, radiant, and protected skin.

4. Complete protection against external stress factors

The formula with edelweiss stem cells and antioxidants combats free radicals, protects against blue light, and reduces the harmful effects of pollution.

Result: more even and daily-protected complexion.

5. Visible reduction of wrinkles

By boosting collagen synthesis and improving skin density, the cream helps reduce wrinkle depth and visibly smoothes the complexion.

Result: firmer, youthful-looking skin.

*Studies conducted by Bionos Biotech (Valencia, Spain), according to ISO 9001:2015 and GCP standards.

Dermatologist’s advice

Skin aging is a natural process that begins around the age of 20, marked by slight changes that become more pronounced over time. Factors such as genetics, sun exposure, lifestyle, and environmental pollution contribute to the aging process. Among the main “culprits” is collagen degradation, a structural protein that keeps the skin firm and wrinkle-free.

Throughout my experience working with patients, I have observed that this fundamental element of skin health is often overlooked. Over the years, I have encountered many people who underestimated the importance of collagen in their efforts to achieve healthy skin. The truth is that, as we age, our skin undergoes certain natural transformation processes, and collagen levels begin to decline. Unfortunately, this reduction leads to the appearance of visible signs of aging—fine lines, wrinkles, and sagging skin.

In addition to the internal care we provide to our bodies, it is equally important to take care of the exterior. Thanks to this synergy, the full potential of your skin’s beauty and vitality can be unlocked.

Corina Pocnea, Dermatologist and Trichologist

Synergy: How These Ingredients Work Together

What makes this cream truly effective is the synergy between three powerful allies - collagen, Vitamin C, and peptides, which work together to repair and rejuvenate the skin.

Collagen provides structural support, Vitamin C offers a strong defense mechanism against oxidative damage, while peptides stimulate collagen production and improve skin texture.

The inclusion of SPF 25 in the formula ensures that these efforts are not in vain. By protecting your skin from the sun's harmful rays, you prevent further damage and maintain the youthfulness and health of your skin.

The inclusion of SPF 25 in the formula ensures that these efforts are not in vain. By protecting your skin from the sun's harmful rays, you prevent further damage and maintain the youthfulness and health of your skin.

The Power of Vitamin C

Over time, our skin’s ability to combat oxidative stress diminishes. This is where Vitamin C comes in – a potent antioxidant that fights free radicals, those molecules that accelerate aging and cause damage to the skin.

By stimulating collagen production and enhancing skin firmness, our highly stable Vitamin C formula is gentle enough even for sensitive skin.

Collagen: 'Strengthening the Foundation'

Collagen acts as a kind of 'skeleton' that maintains the skin’s structure, being the most important component in the fight against aging.

In our formula, we’ve included a complex of 9 types of collagen with varying molecular weights, which penetrate both the epidermis and dermis. This helps restore the skin’s elasticity and reduce visible signs of aging.

The Magic of Peptides

We’ve opted for a combination of 5 powerful peptides that play a crucial role in repairing and renewing the skin.

These small but mighty molecules function as messengers that instruct cells to produce more collagen, restoring the skin’s natural elasticity and suppleness, and helping reduce wrinkles.

These can be considered the “building blocks” that support the skin’s structure.

The Impact of Sun on Skin Aging

Now, let’s address the importance of sun protection against UV rays. Sun exposure is one of the most significant factors contributing to premature skin aging.

The sun’s harmful UV rays can destroy collagen and elastin fibers, leading to wrinkles, pigmentation, and sagging skin lacking firmness.

Our cream acts as a protective shield, blocking these harmful rays and helping prevent further damage.

In conclusion, maintaining youthful and radiant skin depends not only on genetics but also on making informed decisions in your skincare routine, being aware of the aging process, and acting proactively in response. Collagen is the most important component of the skin matrix, so the impact of preserving and stimulating collagen production in the skin should not be underestimated. Restoring and strengthening collagen levels is equivalent to maintaining skin health, which manifests as smooth, firm, radiant skin with a youthful appearance.

Key active ingredients
  • Complex of 9 types of collagen
  • 1% Stabilized Vitamin C
  • 4.5% Multi-peptide Complex
  • Edelweiss stem cells
  • Aloe vera juice and botanical extracts

Sun protection

  • Advanced UV filters with SPF 25 protection
  • High UVA protection — PA+++

Complex of 9 types of Collagen

The formula includes 9 types of collagen with different molecular weights, which penetrate both the epidermis and the dermis.

High molecular weight collagen targets the epidermis (the upper layer of the skin), while lower molecular weight collagen penetrates into the deeper layers of the skin.

Therefore, this collagen complex provides a series of benefits:

  1. Retains water in the skin, keeping it hydrated and soft.
  2. Helps achieve a smoother and finer skin texture, giving it a more youthful appearance.
  3. Contributes to strengthening the skin barrier, which protects against environmental stress factors.

Stabilized Vitamin C (1%)

Stabilized Vitamin C is found in a safe, efficient form that does not irritate and easily penetrates the skin. Transforming into ascorbic acid, it penetrates the deep layers of the skin.

  1. Promotes collagen synthesis, increasing elasticity and firmness of the skin.
  2. Combats uneven skin tone.
  3. Provides strong antioxidant protection, helping cells fight the harmful effects of free radicals*, which contribute to premature aging.
  4. Improves skin radiance, giving it a natural healthy glow and reducing dullness.
  5. Has an anti-inflammatory effect.

*Free radicals are aggressive molecules that damage cellular lipids, as well as collagen and elastin fibers in the skin. Their impact leads to signs of photoaging, including pigmentation, dryness, loss of elasticity, uneven skin tone, and reduced skin density.

Multi-peptide Complex (4.5%)

A blend of 5 different peptides improves the quality of collagen, making the skin fuller, smoother, and firmer, restoring its elasticity. The advantage of using a peptide complex lies in their synergistic interaction. It:

Therefore, this collagen complex provides a series of benefits:

  1. Revitalizes the skin
  2. Reduces the appearance of fine lines and wrinkles
  3. Improves skin firmness and elasticity
  4. Stimulates collagen production
  5. Enhances skin turgor* and density, providing a lifting effect.

*In dermatology, “turgor” refers to the skin’s elasticity and its ability to change shape and return to normal. It is an important indicator of hydration levels and overall skin health.

Edelweiss Stem Cells

Stem cells from edelweiss are used to combat photoaging caused by both infrared (IR) and ultraviolet (UV) radiation, mimicking nature's defense mechanisms against sun damage to plants. Additionally, they provide protection against blue light exposure.

UV Filter (SPF 25, PA+++)

UV filters are essential for protecting the skin from the harmful effects of ultraviolet rays, preventing premature aging. They act as a protective shield by absorbing and dispersing UV radiation, thus protecting the skin. UV filters help combat the harmful effects of UV rays on the collagen in the skin. Specifically, UVB and UVA rays destroy collagen fibers in the deeper layers of the skin. Applying cream with UV protection reduces these harmful effects, protecting collagen and contributing to maintaining the health and youthful appearance of the skin.

Aloe Vera Juice and Botanical Extracts

Aloe vera juice deeply hydrates and regenerates the skin while also providing soothing properties.
Red currant extract acts as a powerful antioxidant and anti-inflammatory agent, protecting skin cells from free radicals and significantly slowing down signs of aging.
Licorice root extract evens out skin tone, reducing redness and pigmentation spots.

INCI

AQUA, ETHYLHEXYL METHOXYCINNAMATE, DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE, PROPYLHEPTYL CAPRYLATE GLYCERIN, ALCOHOL, NATURAL COLLAGEN COMPLEX HD COLLAGEN EXTRACT (AND) COLLAGEN AMINO ACIDS (AND) COLLAGEN (AND) SOLUBLE COLLAGEN (AND) HYDROLYZED COLLAGEN (AND) SOLUBLE COLLAGEN CROSSPOLYMER (AND) POTASSIUM MYRISTOYL HYDROLYZED COLLAGEN (AND) ROSIN HYDROLYZED COLLAGEN (AND) ATELOCOLLAGEN (AND) 1,2-HEXANEDIOL (AND) WATER), CAPRYLIC, CAPRIC TRIGLYCERIDE, C12-15 ALKYL BENZOATE, CETEARYL ALCOHOL COCO-CAPRYLATE, BIS-ETHYLHEXYLOXYPHENOL METHOXY PHENYL TRIAZINE, DIMETHICONE, HYDROGENATED VEGETABLE GLYCERIDES, BUTYROSPERMUM PARKII (SHEA) BUTTER, SODIUM ASCORBYL PHOSPHATE, DIMETHYL ISOSORBIDE, POLYSORBATE 20, PHENOXYETHANOL, ALOE BARBADENSIS LEAF JUICE, SODIUM POLYACRYLATE, SODIUM STEAROYL GLUTAMATE, VACCINIUM VITIS-IDAEA FRUIT EXTRACT, TOCOPHEROL, XANTHAN GUM, ACETYL TETRAPEPTIDE-11, ACETYL TETRAPEPTIDE-9, VACCINIUM MACROCARPON (CRANBERRY) FRUIT EXTRACT, GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT, CITRIC ACID, TETRASODIUM EDTA, ETHYLHEXYLGLYCERIN, GLUCONOLACTONE, CALCIUM GLUCONATE, SODIUM BENZOATE, TETRADECYL AMINOBUTYROYLVALYLAMINOBUTYRIC UREA TRIFLUOROACETATE, PALMITOYL TRIPEPTIDE-5, PALMITOYL DIPEPTIDE-5 DIAMINOBUTYROYL HYDROXYTHREONINE.

Apply a moderate amount of cream to the clean, dry skin of the face, neck, and décolleté.

Gently massage with upward motions until the product is fully absorbed.

For optimal results, use daily in the morning as the final step in your skincare routine, before sun exposure or applying makeup.

The cream provides efficient protection against UVA/UVB rays, making it ideal for daily use regardless of the season.

How to apply

1. Cleanse your complexion – Wash your face with a gentle cleanser and pat it dry with a clean towel.

2. Apply a serum or essence (optional) – If you're using a serum with vitamin C, hyaluronic acid, or other active ingredients, apply it before the cream and allow it to absorb.

3. Take an appropriate amount – A dose about the size of a pea is sufficient for the face and neck.

4. Gently massage – Apply the cream with upward circular motions on the face and neck, avoiding the eye area.

5. Allow it to absorb – Wait 2-3 minutes before applying makeup or other products.

6. Reapply if necessary – If you spend a lot of time outside or are exposed to the sun, reapply every few hours for optimal SPF protection.

7. Use daily in the morning for hydrated, protected, and youthful-looking skin!

Storage conditions

  • Store at temperatures between 5°C and 25°C.
  • Keep away from direct sunlight.

Precautions
  • Keep out of reach of children.
  • Avoid contact with eyes. In case of contact, rinse immediately with plenty of water.
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CLINICALLY PROVEN

Smoother and more elastic skin in just 28 days*

* In vivo clinical study conducted by Bionos Biotech (Spain, 2024), average efficacy measured instrumentally on 20 volunteers after 28 days by us.

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+14.5%

Increase in skin elasticity

11.2%

Reduction in wrinkle volume

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CLINICALLY PROVEN

Stimulation of collagen synthesis in skin tissues

* In vitro study conducted by Bionos Biotech (Spain, 2024). Confocal microscopy was used to evaluate the effects of SPF 25 Cream on collagen biosynthesis in human fibroblasts from skin explants.

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+30.8%

Increase in skin collagen biosynthesis

-43,3%

Reduction of collagen degradation

Benefit Image Benefit Image

+30.8%

Increase in skin collagen biosynthesis

-43,3%

Reduction of collagen degradation

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The complete routine for your skin's beauty

The Cream SPF 25 · Hydrolyzed Marine Collagen Liquid

The complete routine for your skin's beauty

The Cream SPF 25 · Hydrolyzed Marine Collagen Liquid

Consuming liquid collagen and applying collagen cream can have a synergistic effect. Liquid collagen works from the inside out, stimulating the body's natural collagen production, while collagen cream nourishes and hydrates the skin on the surface, contributing to a firmer, younger appearance.

Collagen cream provides deep and immediate hydration to the skin, protecting it from dehydration. Liquid collagen helps maintain skin hydration from within, thus ensuring healthier and younger-looking skin.

Liquid collagen helps to stimulate skin elasticity from the inside, reducing wrinkles and fine lines over time. Collagen cream complements this effect, providing a smoother, more supple appearance to the skin on the outside.

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Products with the power of 21Collagen

Discover complete beauty, enhanced from the inside and out, with our essential products, created by 21Collagen experts and validated through rigorous clinical studies.

Products with the power of 21Collagen

Discover complete beauty, enhanced from the inside and out, with our essential products, created by 21Collagen experts and validated through rigorous clinical studies.

10,000 mg of premium liquid marine collagen peptides, enriched with 21 complementary boosters to improve the health of skin, hair, and nails.

This mask smooths, hydrates, and brightens the skin from the very first use. Enriched with SymCalmin®, it reduces redness and evens out skin tone for a fresh, radiant appearance.

10,000 mg of premium liquid marine collagen peptides, enriched with 21 complementary boosters to improve the health of skin, hair, and nails.

This mask smooths, hydrates, and brightens the skin from the very first use. Enriched with SymCalmin®, it reduces redness and evens out skin tone for a fresh, radiant appearance.

Frequently Asked Questions

Still have questions? Visit our Help Center or ask at hello@21collagen.com

The Cream SPF 25 draws in and locks in moisture, delivering deep, effective hydration to the skin. It helps keep your facial skin soft and supple, enhancing elasticity and overall appearance. Plus, the cream smooths out wrinkles, visibly reducing signs of aging and leaving the skin looking rejuvenated and revitalized.

Apply the cream every morning after washing and cleansing your face. Evenly spread over the face, neck, and décolleté, then massage until fully absorbed.

The cream is suitable for all skin types, but we particularly recommend it for mature skin (25+), as its formula specifically targets wrinkles and skin dehydration.

The Cream SPF 25 stimulates the natural production of collagen, helping to maintain skin firmness and elasticity. In 28 days, it reduces the depth of wrinkles by 11.2%, clinically proven results! It ensures effective skin regeneration, reducing signs of aging and providing a revitalized and healthy appearance. In addition, with the help of UV filters in the formula, it protects against the degradation of the skin's own collagen, thus preventing the loss of skin structure and tone. Its formula contains active ingredients that work synergistically to improve the texture and appearance of the skin, providing intense hydration and long-lasting protection. Among the main ingredients we have: 9 types of collagen, 1% vitamin C, 4.5% multipeptide complex, UV filters.

The cream is valid for 24 months from the date of production and 6 months after opening the product.

People with problematic, sensitive, acne-prone, rosacea-prone, or other skin conditions should consult their doctor before using The Cream SPF 25. Although the cream contains natural ingredients, the oils and vitamin C in its formulation may not be suitable for skin that is sensitive to these components.

The Cream SPF 25 can be easily incorporated into your skincare routine alongside any creams, serums, toners, or other products. It can be used with acids, but you should avoid applying it at the same time as retinol-containing products. However, since The Cream SPF 25 is recommended for morning use and retinol is used in the evening, the two products do not conflict with each other.

The Cream SPF 25 is formulated with natural, safe ingredients. An allergic reaction or irritation may occur only if you have very sensitive skin or an individual intolerance to a specific ingredient in the formula—for example, vitamin C or certain botanical extracts.

There are no restrictions on the use of the cream for pregnant or breastfeeding women.

Yes, there are clinical studies conducted on The Cream SPF 25. Clinically proven properties – smoother and more elastic skin in just 28 days, +14.5% increases skin elasticity, 11.2% decreases wrinkle depth. In vivo clinical study conducted by the company Bionos Biotech (Spain, 2024), with evaluation of the average efficiency measured instrumentally on 20 volunteers after 28 days of use.

The Cream SPF 25 is an anti-wrinkle day cream that combines sun protection with the benefits of hydrolyzed collagen to provide intense hydration and prevent signs of skin aging. Its lightweight formula absorbs quickly, protecting the skin against UVA and UVB rays, while stimulating cell regeneration and maintaining an optimal level of elasticity.

Rich in antioxidants and nourishing ingredients, this cream helps visibly reduce fine wrinkles and gives the skin a firmer and brighter appearance throughout the day.

Customers who have tested The Cream SPF 25 highlight fast and long-lasting results, mentioning smoother skin, reduced wrinkles and an added glow. Many women appreciate the fine texture, suitable for all skin types, as well as the fact that it can be applied as a makeup base, without leaving greasy marks. The reviews you can find on the site confirm that integrating this cream into your daily care routine accelerates the skin regeneration process and provides an effective barrier against harmful environmental factors.

The efficiency and quality of 21Collagen hydrolyzed liquid marine collagen, SPF15 cream, and collagen moisturizing mask are proven not only by the awards in the palmares, but also by user reviews.

Anca Serea , an influencer from Romania, claims that she felt the positive effects of collagen on her skin and that her skin quality became much better.

Maria Rocsana, a digital creator from Romania, and Ioana Popa, a content creator from Romania, were also pleasantly surprised by the effects felt on their skin, nails, and joints after using and introducing liquid collagen into their routine.

21Collagen formulas are developed based on the results obtained in clinical studies and tests, guaranteeing efficiency and safety. Dermatologists and skin care specialists recommend the brand's products due to the high-quality collagen and carefully selected ingredients. The synergy between collagen, sunscreens and active nutrients helps combat premature aging and keeps the skin healthy, supple and protected. By choosing 21Collagen, you benefit from a premium experience and the trust of professionals in the field.