What is collagen?

Collagen is not just a protein, but the foundation that supports skin elasticity, bone strength and joint flexibility. Think of it as an “invisible skeleton” that keeps the body strong, supple and healthy. It is an essential component of the extracellular matrix, that sophisticated network that provides structure and protection to tissues. But collagen is not limited to being a simple support – it actively interacts with cells, influencing skin regeneration, elasticity and firmness.

Types of collagen

Of the 28 types of collagen discovered, five are essential for our health and beauty:

Type I – The most abundant (over 90% of the body’s collagen), it provides strength to the skin, bones, tendons, and ligaments. It is the key to firm, youthful skin.

Type II – The friend of the joints, found in cartilage, maintaining flexibility and preventing joint discomfort.

Type III – Found in skin, muscles, and blood vessels, supporting elasticity and regeneration.

Type IV – Plays a crucial role in forming the base layer of the skin, providing support and protection.

Type V – Found in the cornea, hair, skin, and placenta, contributing to their structure and health.

Natural Collagen vs. Collagen from Supplements

Our bodies naturally produce collagen (endogenous collagen) by processing amino acids from protein-rich foods such as meat, fish, and eggs. However, this production decreases with age, which is why collagen supplements become an effective solution.

Exogenous collagen, found in supplements, is usually hydrolyzed, meaning broken down into small, easily absorbable peptides. The secret to maximum absorption? Combining it with vitamin C, which stimulates collagen synthesis and optimizes its bioavailability in the body.

What are the forms of collagen found in dietary supplements?

Most supplements contain collagen types I, II, and III, as these are most relevant to skin, joints, and connective tissues. Depending on the source, collagen can come from:

✔️ Bovine bones and tissues
✔️ Marine sources (fish skin and scales)
✔️ Poultry and pigs

Properties and benefits of hydrolyzed collagen (collagen peptides)

It dissolves completely in cold or hot liquids, making it easy to integrate into the diet.

They are concentrated in protein (over 90%) and contain eight of the nine essential amino acids, with high levels of proline, glycine and hydroxyproline.

They support joint and bone health, while also improving the appearance of skin, hair and nails.

They can help repair damaged skin, reduce joint pain, and even increase bone density.

They can improve intestinal health and accelerate recovery in athletes, by shortening recovery times and optimizing joint function.

Some research suggests that collagen peptides could contribute to weight loss and reduction in body fat percentage, especially when combined with physical activity and, implicitly, increased muscle mass.

Collagen can also increase levels of the hormone responsible for establishing a feeling of satiety, supporting appetite management.

21Collagen's Hydrolyzed Liquid Marine Collagen contains type 1 and 3 collagen and an exclusive combination of 21 ingredients, designed to be a true elixir for skin and whole body health. The product is based on the most comprehensive liquid marine collagen formula, approved by numerous clinical tests, studies, and experts in the field. You can find more details in the first block on the 21collagen page.

Benefits of collagen

Collagen is the essential protein that supports the structure of skin, hair, nails and joints, playing a fundamental role in maintaining their elasticity and firmness. Collagen supplementation significantly contributes to maintaining the overall health of the body:

Firmer and more hydrated skin

Collagen plays an essential role in maintaining skin elasticity and preventing premature aging. Combining it with vitamin C stimulates natural collagen synthesis, improving firmness and reducing fine lines.

Stronger and shinier hair

Collagen provides the amino acids necessary to support the structure of the hair, preventing it from thinning and giving it a healthy and shiny appearance.

Stronger nails

Collagen deficiency can lead to brittle and weak nails. Supplementing with collagen and essential vitamins can help strengthen them and help them grow faster.

Healthier and more flexible joints

Collagen is a major component of cartilage, giving it strength and elasticity. Supplementation helps reduce joint discomfort and maintain optimal mobility.

To discover the specific benefits of 21Collagen liquid hydrolyzed marine collagen, we invite you to explore the information block above, where you will learn how its advanced formula contributes to the health of your skin, hair, nails, and joints.

Clinical trial results

21Collagen hydrolyzed liquid marine collagen has undergone several clinical trials to the highest standards. One of them was a randomized, double-blind, placebo-controlled clinical trial on 71 subjects. They consumed a daily dose of 30 ml of 21Collagen for 13 weeks. After the 7th week, a 32.1% increase in skin elasticity was clinically proven.

What does increasing skin elasticity mean?

1. Improves skin firmness and tone: Increased elasticity helps improve the structure of the dermis’ own collagen and elastin, two proteins essential for maintaining skin strength and tone. This allows the skin to maintain its shape without “sagging”. Dermatological studies show that skin with greater elasticity has a better ability to adapt to volume changes, which reduces the risk of wrinkles and sagging skin.

2. Reduce fine lines and wrinkles: Improved elasticity helps restore the structure of fibroblasts, the cells that produce collagen and elastin, which are essential for maintaining the smooth texture of the skin. According to dermatological research, skin with high elasticity is better able to stretch and return to its original shape without forming cracks, thus reducing the formation of fine lines and wrinkles, which are caused by the loss of this ability to return.

3. Prevents stretch marks: Increasing skin elasticity helps prevent stretch marks by improving the integrity of the dermis, the deeper layer of skin that supports collagen and elastin. During periods of rapid growth (such as pregnancy or weight changes), elastic skin can stretch without breaking collagen fibers, preventing the appearance of stretch marks. Dermatological studies highlight that more elastic skin has an increased ability to adapt to rapid changes in volume, thus protecting the skin from stretch marks.

4. Faster recovery from stressors: Elastic skin has a greater ability to adapt to mechanical and environmental stress. This is due to an improved network of collagen and elastin, which are responsible for skin regeneration and repair. According to dermatological research, more elastic skin recovers faster after exposure to external factors such as UV rays or pollution, minimizing the damage caused by these factors and maintaining youthful and resilient skin.

Products from the 21Collagen range

To take advantage of all the benefits of collagen, we support its integration not only orally, but also in cosmetic products. 21Collagen offers you 3 suitable products to complete your beauty routine:

Hydrolyzed Marine Collagen Liquid , containing 10,000 mg of premium marine collagen peptides, enriched with 21 complementary boosters, for firmer skin, healthier hair and stronger nails. The Cream SPF 25, a formula advanced with collagen and SPF, which offers clinically proven results: smoother skin in just 28 days, support for collagen synthesis and protection against UVA rays.

The Collagen Mask, an intense treatment that smoothes, hydrates and brightens the skin from the first use, with calming effects thanks to the ingredient SymCalmin®, which reduces redness and evens out skin tone.

If you want to complete your routine with products from the 21Collagen range and save money, take advantage of our offers on sets. Receive effective products that will last you a longer period of time and at the same time save you from extra expenses. Find the offers on sets in the menu of the 21collagen.ro website.

What are the signs of decreased collagen levels?

As we age, the body produces less and less collagen, and the existing collagen degrades more quickly. Women especially experience this decrease after menopause, and after the age of 60, it is natural for anyone to experience a significant decline in the amount of collagen.

Although there is no precise method for measuring collagen concentration in the body, we can identify certain clear signs that suggest reduced production of this essential protein.

The most common symptoms include:

the appearance of wrinkles

loss of skin firmness and elasticity

muscle pain and weakness

stiffness in tendons and ligaments

Joints can become painful or conditions like osteoarthritis can set in due to damaged cartilage. In addition, thinning of the digestive tract lining can cause gastrointestinal discomfort, and circulatory problems can be exacerbated by decreased collagen synthesis.

All these manifestations may signal that the body needs an additional supply of collagen to maintain its functions and mobility in optimal parameters.

8 Signs of Collagen Deficiency

Arthritis and joint pain

Collagen is an important component of joint cartilage, which helps support and protect joints. When collagen levels are low, cartilage can break down more easily, leading to inflammation, pain, and joint stiffness. This can increase the risk of arthritis and other joint problems.

Wrinkles and sagging skin

Collagen is a key structural protein in the skin, contributing to elasticity and firmness. A collagen deficiency reduces the skin's ability to maintain its firmness, leading to wrinkles, fine lines and the appearance of sagging skin (premature aging).

Slow wound healing

The wound healing process involves the production and remodeling of collagen in damaged tissues. Inadequate collagen levels can slow tissue regeneration, leading to slower healing of cuts, burns, or other injuries.

Hair loss

Collagen contributes to scalp health and hair structure, helping hair to be strong and resistant to breakage. When the body has a collagen deficiency, hair can become more fragile and break or fall out more easily.

Brittle nails

Like hair, nails also need enough collagen to maintain their strength and elasticity. If collagen levels decrease, nails can become thinner, brittle, and prone to peeling or breaking.

Immunity problems

Although collagen is primarily known for its structural role, it is also involved in overall tissue health. By maintaining the integrity of mucous membranes (body barriers) and supporting cell regeneration, sufficient collagen levels can help protect the body against infection. A deficiency can reduce this protection, increasing susceptibility to disease.

Low bone density

Bones contain collagen proteins in their structure that provide strength and flexibility. If collagen synthesis is deficient, bones can become more fragile, which increases the risk of osteoporosis and fractures.

Food sensitivities

People with collagen deficiencies may also experience problems with intestinal permeability (so-called “leaky gut”). When the intestinal wall lacks sufficient structural support, the barrier against unwanted molecules can be compromised. This can lead to adverse reactions to certain foods and increase food sensitivities.

Causes of rapid collagen loss in the body

Low-nutrient diet

A diet that lacks quality protein, essential vitamins and minerals, such as vitamin C, zinc and copper, can limit normal collagen synthesis. The body needs certain amino acids to produce this structural protein, and when these are lacking, production decreases.

Excessive sun exposure

Ultraviolet (UV) rays damage the collagen fibers in the skin and stimulate the formation of free radicals, which accelerate the aging process. If adequate protection is not used (sunscreen, appropriate clothing), the collagen in the skin degrades more quickly.

Chronic stress and lack of sleep

Constant stress and insufficient rest increase the level of cortisol in the blood. Excess cortisol affects the body's natural repair mechanisms, including collagen production. In addition, vital regenerative processes for protein synthesis occur during sleep, which means that sleep deprivation can significantly slow down these processes.

Smoking

Cigarette smoke contains toxic chemicals that damage blood vessels and reduce the flow of nutrients to the skin. Nicotine and other compounds in cigarettes can also inhibit collagen production and promote its breakdown, leading to premature wrinkles and loss of skin elasticity.

Excessive alcohol consumption

Alcohol reduces the body's ability to absorb and metabolize nutrients needed for collagen synthesis. It also causes dehydration and damages the liver, the organ responsible for detoxification and regulation of metabolic processes. All of these effects are reflected in the degradation and decrease in collagen production in the body.

Collagen from dietary supplements vs. Cosmetic collagen

Collagen supplements are available in various forms: liquids, powders, capsules or jellies. This essential protein is the foundation of skin, nails, hair, joints and bones. Although it is often associated with improving the appearance of the skin and strengthening the hair, collagen has much more extensive effects: More hydrated and elastic skin, Healthier and more flexible joints, Stronger hair and nails.

On the other hand, cosmetic collagen has visible effects on the surface. Collagen-based cosmetic products are quick fixes for a rejuvenated appearance of the skin. Many anti-wrinkle treatments and fillers contain collagen combined with hyaluronic acid and other fillers, having an instant lifting effect.

Cosmetic collagen is used to reduce wrinkles, improve facial contours, and fade scars.

If you want visible long-term results, we encourage combining collagen intake from both cosmetic sources and dietary supplements. On our website you can find a special block dedicated to studies and clinical tests conducted on 21Collagen products.

Over 2+ years of research, conducted in collaboration with experts in dermatology and nutrition, and testing of 12 collagen compositions by over 150 participants, we have arrived at the most advanced and beneficial collagen formula for the body.

Why do Experts Trust Collagen?

Over the years, collagen has been studied in depth due to its essential role in maintaining the structural integrity of tissues and the numerous benefits associated with healthy aging.

A telling example is a systematic review and meta-analysis published in April 2023 by PubMed Central , which brought together 26 controlled clinical trials (RCTs) and 1721 participants. This study aimed to evaluate the effects of hydrolyzed collagen (HC) supplementation on skin hydration and elasticity.

The results obtained revealed a significant improvement in both hydration and skin elasticity compared to a placebo group.

Subgroup analyses suggested that the source of collagen and duration of supplementation may influence the effects obtained, but no significant differences were found in elasticity.) Although potential errors and confounding factors were reported in the included RCTs, the overall conclusions indicate that the administration of hydrolyzed collagen may have a positive impact on maintaining and improving skin health.

A second example, published on ScienceDirect , highlights the importance of collagen as a major component of the extracellular matrix in the dermis and articular cartilage, being associated with mechanical, organizational and tissue-forming properties. The study shows that, thanks to its origin from food industry by-products, collagen is considered a versatile ingredient and supplement with remarkable benefits in the food, pharmaceutical and cosmetic fields.

According to this analysis, supplementation with hydrolyzed collagen generates positive effects, such as reducing wrinkles, increasing skin elasticity and hydration, as well as improvements in bone density, joint stiffness and mobility.

These conclusions support the therapeutic and preventive potential of collagen, and the liquid marine hydrolyzed product from 21Collagen, subjected to numerous tests and evaluations, has gained the trust of specialists and health experts precisely through its remarkable results on the condition of the skin and the musculoskeletal system, thus contributing to maintaining optimal well-being and slowing down the natural aging process.

On our website you will find a special block dedicated to experts who support and trust 21Collagen. Among them are Alexandra Bǎlasa (Resident Endocrinologist),Olga Grosu (Cosmetologist Aesthetician),Elena-Ana Ramaşcanu (Resident Dermatologist), Cristina Oboroc (Facefitness Expert, Cosmetician).

21Collagen Awards

Of the many collagen-based products on the market, few manage to win medals at international competitions. These awards are granted following rigorous analysis and meeting strict criteria, which include the superior quality of the formula, eco-friendly packaging, and compliance with all recognized European quality standards.

21Collagen is among the few products that have consistently won awards in such competitions since its first appearance, and a few examples confirm its top position:

Monde Selection 2024 - An independent international institute that evaluates the quality of consumer products, awarding distinctions based on criteria such as taste, composition, presentation and innovation. The fact that 21Collagen received the "Gold Award" attests to the high standards of quality and special attention to detail.

Pure Beauty Awards - A prestigious event that promotes and rewards innovation in the beauty and personal care industry. The nomination as a finalist placed 21Collagen in a select category of revolutionary products, remarkable for their effectiveness and innovative formula.

Global Green Beauty Awards - A competition that emphasizes sustainability and environmental protection, rewarding brands that use eco-friendly ingredients and packaging that is friendly to the planet. The "Silver" award given to 21Collagen reflects the manufacturer's dedication to providing a responsible and sustainable product, in perfect harmony with international standards.

You can find more information and details on our blog, where we answer the most frequently asked questions and describe our 21Collagen products from A to Z.

User reviews

The efficiency and quality of 21Collagen hydrolyzed liquid marine collagen, SPF15 cream, and collagen moisturizing mask are proven not only by the awards in the palmares, but also by user reviews.

Anca Serea , an influencer from Romania, claims that she felt the positive effects of collagen on her skin and that her skin quality became much better.

Maria Rocsana, a digital creator from Romania, and Ioana Popa, a content creator from Romania, were also pleasantly surprised by the effects felt on their skin, nails, and joints after using and introducing liquid collagen into their routine.

Top 3 Reviews of 21Collagen

Daniela Rotari : “I started using 21Collagen 3 months ago and I can say that I am extremely satisfied with the results! My complexion is much firmer and more elastic, and my skin feels much more hydrated, my hair has started to grow visibly, it looks healthier than ever! I am very pleased with these improvements and will continue to use 21Collagen collagen in the long term. I highly recommend it!”

Denisa Ștefan : “I have been using the product for 2 months. It has a pleasant, dense, sweet taste and is easy to administer. My hair no longer falls out as much and my skin looks much better. I recommend it!”

Dumitrița Popa : “Since I started using 21 Collagen, the difference is remarkable! My skin looks much more hydrated and full of life, and fine lines have started to visibly fade. I am impressed by how well it absorbs and the pleasant taste. In addition, I have noticed my hair is shinier and my nails are stronger. It is truly a reliable product that has kept all its promises.”

Frequently asked questions about collagen

On our website you can also find answers to the most frequently asked questions about collagen. Are you curious about whether you can use collagen while breastfeeding or what restrictions there are regarding this supplement? Read the explained answers to these questions in the Frequently Asked Questions section.

For example, the top most popular questions about collagen include:

What are the risks associated with taking collagen?

Collagen is generally well tolerated and side effects are rare. However, some users may experience bloating, heartburn, or fullness. It is essential to consider the source of the collagen you choose: bovine or marine, depending on your preferences and needs. For example, those with fish allergies should avoid marine collagen supplements, and people with a strict vegan lifestyle may prefer not to use bovine collagen.

Note: We do not recommend 21Collagen to people allergic to fish products.

Is collagen suitable for people with diabetes?

There are a wide variety of collagen supplements available, and their ingredients can vary significantly. Some versions contain sugar or artificial sweeteners, which can be a problem if you're watching your blood sugar levels. So it's always a good idea to check the label and talk to your doctor before trying a new supplement.

21Collagen's liquid collagen drink contains no added sugar, but a natural sweetener, specially chosen to be more friendly to people who carefully monitor their blood sugar. However, even though we are talking about a safe product with a carefully thought-out formula, we recommend that everyone, especially those with conditions such as diabetes, consult their doctor before including it in their daily routine.

Can I take collagen supplements if I am pregnant/breastfeeding?

Collagen supplements are not recommended for pregnant or breastfeeding women. Consult your doctor before taking collagen.

How long will it take for me to see the effects of collagen?

Depending on the type of collagen you choose, the rate at which results appear may vary. For example, powdered supplements may have a slower onset of action, as the assimilation process may take longer.

On the other hand, liquid collagen is absorbed faster, which means that results can be visible sooner. For this reason, 21 Collagen has been formulated in liquid form, enriched with carefully selected ingredients, to accelerate the regeneration process and support optimal assimilation.

Corina Pocnea, author of the 21Collagen formula

In the lower segment of our website, the focus is on the presentation of Corina Pocnea , dermatologist and trichologist, also the author of the 21Collagen formula . She talks about the unique formula of 21Collagen liquid collagen and its positive impact on the body.

Dr. Corina Pocnea makes a remarkable contribution to the development and refinement of the 21Collagen product range through her valuable expertise in dermatological science and deep understanding of the diverse needs of the skin. In the R&D team, she assumes the role of skincare expert and cosmetic product creator, guaranteeing not only the efficacy, but also the safety of each product for a variety of skin concerns, addressing all skin types.

By actively participating in the creative process, Dr. Corina Pocnea knows each product in detail, offering a unique perspective on how each formula can meet the specific needs of her patients. She ensures that the products undergo clinical testing in prestigious laboratories in Europe, guaranteeing their level of excellence.

The internet is full of information about collagen and its benefits, but not all sources are based on solid scientific evidence. To separate the unfounded theories from the conclusions supported by research, we have compiled a comprehensive selection of the five most valuable articles dedicated to collagen, its administration and benefits. These materials base their conclusions on studies published in prestigious journals, such as the Journal of Drugs in Dermatology , Nutrients and the British Journal of Nutrition , thus constituting reliable references for those interested in a correct understanding of the role of collagen in the body's health.

When to Drink Collagen for Maximum Effect

Best Collagen For Knees

10 Signs of Collagen Deficiency

Collagen in Breastfeeding: Benefits and Importance for Mother and Baby Health

Collagen Consumption During Pregnancy: Benefits and Risks According to Studies

Bibliography:

Study Impaired collagen maturity in vitamins B2 and B6 deficiency--probable molecular basis of skin lesions: https://pubmed.ncbi.nlm.nih.gov/6651795/

Collagen supplementation in skin and orthopedic diseases: A review of the literature: https://www.sciencedirect.com/science/article/pii/S2405844023021680

Study Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis: https://pmc.ncbi.nlm.nih.gov/articles/PMC10180699/

Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge: https://pmc.ncbi.nlm.nih.gov/articles/PMC10058045/

Efficacy and tolerability of an oral supplement containing amino acids, iron, selenium, and marine hydrolyzed collagen in subjects with hair loss (androgenetic alopecia, AGA or FAGA or telogen effluvium). A prospective, randomized, 3-month, controlled, assessor-blinded study: https://pubmed.ncbi.nlm.nih.gov/37357646/

Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/β-Catenin and BMP Signaling Pathways: https://pubmed.ncbi.nlm.nih.gov/36233206/

Oral hyaluronan relieves knee pain: a review:https://pmc.ncbi.nlm.nih.gov/articles/PMC4729158/

Biotin: Benefits and Side Effects:https://www.webmd.com/diet/health-benefits-biotin

Effect of dietary thiamine on intermolecular collagen cross-linking during wound repair: a mechanical and biochemical assessment: https://pubmed.ncbi.nlm.nih.gov/6120245/

Zinc Protects Articular Chondrocytes through Changes in Nrf2-Mediated Antioxidants, Cytokines and Matrix Metalloproteinases:https://pmc.ncbi.nlm.nih.gov/articles/PMC5946256/

Author: Health Blogger Mihaela Roibu

Written by: Corina Pocnea